Neural oscillations in bipolar disorder: Exploring right hemispheric abnormality using auditory steady-state magnetic fields.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860934
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Kyushu University
• Principal Investigator: Oda Yuko 九州大学, 医学(系)研究科(研究院), 特別教員 (70721265)
• Co-Investigator(Kenkyū-buntansha): MAEKAWA Toshihiko 九州大学, 医学研究院, 助教 (40448436)
• Co-Investigator(Renkei-kenkyūsha): TOBIMATSU Shozo 九州大学, 医学研究院, 教授 (40164008)
• Research Collaborator: HIRONAGA Masato
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: bipolar disorder / ASSR / MEG / MRI / binaural / monaural

Outline of Final Research Achievements

In a current status of clinical psychiatry, Therefore, the patients with bipolar disorder (BD) are often misdiagnosed and cannot receive the adequate treatment. This is probably due to the facts that the biological pathology of BD is unrevealed and the diagnostic method and treatment marker are not well developed. Neural circuitry restricted to the primary auditory cortex can be assessed using magnetoencephalography (MEG) - auditory steady-state response (ASSR). In binaural ASSR, a region of interest was marked in supratemporal gyrus. The strong power and increased phase-locking factors (PLFs) in time-frequency domain were robustly observed in normal controls while those of BDs were unremarkable. In monaural ASSR, the results of the PLFs in BDs were considered to be stable with continuation in the right hemisphere. MEG is an equipment that is non-invasive for patients. We will continue to apply ASSR to BD for determining the objective biomarker of BD.

Free Research Field

精神神経科学