The relationships between treatment resistant psychiatric patients and anti NMDA receptor antibodies

2017 Fiscal Year Final Research Report

• Project/Area Number: 26860938
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Yokohama City University
• Principal Investigator: CHIBA Yuhei 横浜市立大学, 医学研究科, 客員研究員 (50722500)
• Research Collaborator: HIAYASU Yoshio ; KATSUSE Omi ; FUJISHIRO Hiroshige ; KAMADA Ayuko ; SUDA Akira ; SAITO Tomoyuki ; IKURA Takahiro ; HATTORI Saki ; ABE Kie ; TOYOHARA Nao ; YAMAGUCHI Hiroyuki
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 精神免疫学 / 脳器質性精神疾患 / 辺縁系脳炎 / 自己免疫性脳炎 / NMDA受容体脳炎 / 橋本脳症

Outline of Final Research Achievements

I investigated the clinical characteristics of the treatment-resistant psychiatric patients with anti NMDA receptor antibodies to reveal the pathological association between anti NMDA receptor antibodies and psychiatric symptoms or cognitive impairments. I reported the case series of patients responded to the steroid pulse therapy and the case series with features of Lewy body dementias. I also reported the relationships between anti NMDA receptor antibodies and cognitive impairment in the treatment-resistant psychiatric patients. This will open the new treatment strategy for the psychiatric patients with autoimmune disturbance.

Free Research Field

精神医学