Association of cognitive impairment with acetylcholine and GABA/glutamatergic function in schizophrenia

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860941
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Wakayama Medical University
• Principal Investigator: Takahashi Shun 和歌山県立医科大学, 医学部, 講師 (10508021)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 統合失調症 / 認知機能障害 / アセチルコリン機能 / GABA/グルタミン酸機能 / 経頭蓋磁気刺激

Outline of Final Research Achievements

The aim of this study was examining association of cognitive impairment with acetylcholine and GABA/glutamatergic function in schizophrenia using transcranial magnetic stimulation (TMS). In assessment of GABA/glutamatergic function using paired pulse TMS (ppTMS), cortical excitability was increased in schizophrenia and it related to cognitive impairment and duration of illness. In assessment of acetylcholine function, we developed effortless measuring system of short latency afferent inhibition (SAI) using TMS and median nerve electrical stimulation, and corrected normal control data in this research period.

Free Research Field

精神生理学