Exploration of novel targets for treating schizophrenia

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860942
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Dokkyo Medical University
• Principal Investigator: Arime Yosefu 獨協医科大学, 医学部, 助教 (80609404)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 統合失調症 / モデルマウス / 抗精神病薬 / 受容体占有率 / 行動 / ワーキングメモリー

Outline of Final Research Achievements

We performed in vivo dopamine D2 receptor occupancy analysis during continuous antipsychotic treatment (haloperidol or olanzapine), and developed the clinically-relevant antipsychotic dose regimen in mice. We observed working memory in chronic saline- and phencyclidine-treated mice, and they showed reduced correct responses in the working memory task, suggesting impaired working memory. We also identified brain regions relevant to working memory impairments in this mouse model. Our results may lead to the identification of novel therapeutic targets for patients with schizophrenia.

Free Research Field

精神神経科学