2017 Fiscal Year Final Research Report
Regulatory mechanism of salience network by antipsychotic agent through dopamine D2/3 receptor
| Project/Area Number |
26860947
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 統合失調症 / 顕現性回路 / ドパミンD2/3受容体 |
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| Outline of Final Research Achievements |
In the present study, we investigated the relationship between estimated dopamine D2/3 receptor occupancy (D2/3R occupancy) and volumes of brain regions within the salience network (SN) by using resting state functional magnetic resonance imaging (rs-fMRI) / volumetry in patients with schizophrenia who were treated with risperidone or paliperidone. Our purpose of the study was to find brain region(s) within SN which has correlation with D2/3R occupancy. With independent component analysis, SN was extracted from their rs-fMRI data. No correlation was found between gray matter volumes in the medial prefrontal cortex, caudate nuclei, anterior insula, thalamus, the parts of which were extracted from SN, and D2/3R occupancy.
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| Free Research Field |
神経画像・神経薬理学
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