Verification of involvement of mitochondrial dysfunction and bipolar disorder using brain specific Ant1 conditional knockout mice

2016 Fiscal Year Final Research Report

• Project/Area Number: 26860956
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Kyoto University (2016); Institute of Physical and Chemical Research (2014-2015)
• Principal Investigator: Kato Tomoaki 京都大学, iPS細胞研究所, 特定研究員 (40598439)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 精神疾患 / ミトコンドリア / 気分障害 / モデルマウス

Outline of Final Research Achievements

In this study, we generated Ant1 conditional knockout (cKO) mice to investigate the relationship between mitochondrial function and bipolar disorder like phenotype manifestation. As a result, we found that Ant1 cKO mice showed behavioral phenotype indicating suppression of impulsivity, especially cognitive impulsivity rather than motor impulsivity. In addition, Ant1 cKO mice showed promotion of serotonin and dopamine metabolism in the nucleus accumbens. These results suggest that mitochondrial function in brains has important roles in regulation of monoamines which act as neurotransmitters and in judgment of the reward value. These molecular mechanisms may be one of causes of bipolar disorder onset.

Free Research Field

精神神経科学