2017 Fiscal Year Final Research Report
Examining feasibility of brain MRI as an objective diagnostic biomarker for glaucoma
| Project/Area Number |
26860971
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Research Collaborator |
Nakazawa Toru 東北大学, 医学部, 教授
Omodaka Kazuko 東北大学, 病院, 助教
Tomita Hiroaki 東北大学, 災害科学国際研究所, 教授
Ono Chiaki 東北大学, 災害科学国際研究所, 助教
Kasahara Yoshiyuki 東北大学, 災害科学国際研究所, 助教
Matsudaira Izumi 東北大学, 加齢医学研究所, 大学院生
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 脳MRI / 客観的評価 / 緑内障 |
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| Outline of Final Research Achievements |
We have been conducted longitudinal data aquisition and have analyzed cross-sectional data including mainly anatomical 3D-T1WI images and clinical visual field information, MD(mean deviation). Voxel-based regressing analysis with SPM12(Statistical Parametric Mapping software 12) revealed that gray matter volume of the specific region in primary visual cortex could correspond to the degree of glaucoma-related visual field loss. Patients with glaucoma are often unaware of their visual field loss because that glaucoma-related visual sensitivity loss starts from periphery of visual field. Our results could be of clinical use for picking up asymptomatic glaucoma by detecting specific atrophy via brain MRI medical checkup.
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| Free Research Field |
脳画像研究
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