2015 Fiscal Year Final Research Report
Synthesis and biological evaluation of 18F-FIBG as a PET imaging agent for the detection of pheochromocytoma
| Project/Area Number |
26860981
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Gunma University |
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Principal Investigator |
Yamaguchi Aiko 群馬大学, 医学(系)研究科(研究院), 特任助教 (80609032)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | PET / 褐色細胞腫 / MIBG |
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| Outline of Final Research Achievements |
The aim of this study was to develop an improved method for the radiolabeling of 18F-FIBG, a 18F labeled analog of MIBG, and evaluate its potential as a PET imaging agent for the detection of pheochromocytoma. Hetero-diaryliodonium salt of N-Boc protected diiodobenzylguanidine was synthesized as a labeling precursor. The two-step conversion from the precursor readily produced 18F-FIBG. The PET image revealed visible 18F-FIBG uptake in the tumor in the subcutaneous pheochromocytoma xenograft mice. Above all, 18F-FIBG constitutes a promising PET pheochromocytoma-imaging agent.
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| Free Research Field |
医歯薬学
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