2016 Fiscal Year Final Research Report
Development of new radiopharmaceuticals targeting amino acid transporter system ASC, and system N
| Project/Area Number |
26860988
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Nagasaki University |
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Principal Investigator |
NISHI Kodai 長崎大学, 原爆後障害医療研究所, 助教 (10719496)
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| Co-Investigator(Renkei-kenkyūsha) |
KOBAYASHI Masato 金沢大学, 健康増進科学センター, 助教 (30444235)
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| Research Collaborator |
NIWA Takahiro
INAGAWA Kohei
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | アミノ酸トランスポーター / System N / ヒスチジン / ヨウ素標識 |
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| Outline of Final Research Achievements |
The aim of study is development of new radiopharmaceutical targeting amino acid transporter system ASC, and system N. Our research group discovered that system N transports the L-histidine(L-His) using our original screening system.
We tried iodine labeling for L-His because L-His was evaluated with promising results as base compound of new radiopharmaceutical targeting system N. As a result, high purity 125I-iodo-L-His(125I-IH) was defecated. According to experiment results, most of 125I-IH was transported into the cells by system L, however system N contributed 15% to transportation of 125I-IH in several tumor cell lines.
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| Free Research Field |
放射性医薬品学
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