Imaging the early response to treatment in patients with interstitial pneumonia with dual-time-point 18F-FDG PET imaging

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860990
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: University of Fukui
• Principal Investigator: Umeda Yukihiro 福井大学, 医学部附属病院, 助教 (80401975)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 特発性間質性肺炎 / 治療効果判定 / FDG / PET

Outline of Final Research Achievements

The aim of this prospective study was to clarify whether dual-time-point 18F-FDG PET imaging results are useful to predict long-term survival of idiopathic pulmonary fibrosis (IPF) patients. Methods: Fifty IPF patients underwent 18F-FDG PET examinations at 2 time points. The standardized uptake value (SUV) at each point and retention index value (RI-SUV) calculated from those were evaluated. Results: A multivariate Cox proportional hazard model showed higher RI-SUV as independent predictors of shorter PFS. On the other hand, multivariate Cox analysis showed higher RI-SUV to be independent predictors of shorter overall survival. In addition, a univariate Cox model showed that positive RI-SUV as a binary variable was a significant indicator of mortality. Conclusion: Our results demonstrate that positive RI-SUV is strongly predictive of earlier deterioration of pulmonary function and higher mortality in patients with IPF.

Free Research Field

呼吸器内科学