Brachytherapy using radiolabeled thermo-responsive polymers that self-aggregate in tumor tissues

2015 Fiscal Year Final Research Report

• Project/Area Number: 26860991
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: Sano Kohei 京都大学, 医学(系)研究科(研究院), 助教 (00546476)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 放射性医薬品・造影剤

Outline of Final Research Achievements

The purpose of this study is to establish a novel internal radiotherapy using thermo-responsive polymers under mild hyperthermia. We newly designed and synthesized non-radiolabeled and radiolabeled polyoxazoline (POZ) derivatives, and evaluated the physicochemical property and in vivo biodistribution in colon26 tumor-bearing mice. We demonstrated that POZ with ethyl and isopropyl groups in side chains (Et-Isp-POZ) had a transition temperature of 39℃ and showed rapid aggregation. Moreover, In-111-labeled Et-Isp-POZ demonstrated a modest tumor uptake and a rapid clearance from normal tissues in tumor-bearing mice. In the future, we will investigate the tumor uptake of In-111-labeled Et-Isp-POZ under mild hyperthermia.

Free Research Field

医歯薬学