2015 Fiscal Year Final Research Report
Development of [18F]FBPA new labeling synthesis method for the spread of Boron Neutron Capture Therapy
| Project/Area Number |
26860994
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
Naka Sadahiro 大阪大学, 医学部附属病院, 薬剤師 (60599843)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | PET / BNCT |
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| Outline of Final Research Achievements |
We tried to develop a novel synthesis of [18F] FBPA for PET inspection to determine the implementation propriety of Boron Neutron Capture Therapy, aimed to improve the inspection number.We compared with the conventional method for solubility in various solvents and it's labeling index using a novel precursor.
As a result, the Boc-BPA-tBu was almost unreacted in all solvents. But we were able to establish a process to de-protection from the label in the present study.In the Cbz-BPA, labeling index of the target was about 35% before de-protection.It was about the same as the labeling index of the conventional method.
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| Free Research Field |
医歯薬学
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