2015 Fiscal Year Final Research Report
Next-generation sequencing approach to detect chemoradiotherapy response in esophageal cancer
| Project/Area Number |
26861003
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 化学放射線感受性 / 遺伝子異常 / 食道癌 |
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| Outline of Final Research Achievements |
Esophageal Squamous Cell Carcinoma(ESCC) is resistant to chemoradiotherapy (CRT); therefore, identification of useful biomarkers predicting CRT response is required. To determine whether gene alterations associate with response to CRT, next-generation sequencingt of ESCC treated with definitive CRT was performed. We carried out whole-exome sequencing, DNA methylation sequencing, and RNA sequencing of 6 pretreatment and 2 recurrent ESCCs. Then, gene alterations of CRT responders were compared with CRT nonresponders. We found that the presence of TP53 mutation could not predict clinical response to CRT. We will analyze in detail for genome, epigenome and transcriptome profiles of ESCC treated with definitive CRT.
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| Free Research Field |
放射線腫瘍学
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