Inhibitory effects of metastasis by the local tumor carbon-ion irradiation

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861029
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: Ma Liqiu 国立研究開発法人放射線医学総合研究所, 重粒子医科学センター, 研究員 (70711539)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 転移抑制 / 炭素イオン線 / 免疫

Outline of Final Research Achievements

Our previous research showed local C-ion treatment was able to repress lung metastasis from distal (non-irradiated) tumor in Colon-26-bearing BALB/c model. In this study, the universal of this phenomenon had been verified by using LM8-bearing C3H/He model. Similar to Colon-26-bearing BALB/c model, lung metastasis from distal tumor was significantly decreased in the mice treated with C-ion irradiation. However, the metastasis suppression from distal tumor was not observed after C-ion irradiation in Colon-26-bearing BALB/c-nu/nu model. These results indicate that C-ion local irradiation has ability to suppress metastasis from distal tumor by whole body immune system. In addition, the C-ion and photon had been compared as a resource for this phenomenon. The result showed that both C-ion and X-ray irradiation significantly repressed lung metastasis from distal tumor.

Free Research Field

粒子線治療