2016 Fiscal Year Final Research Report
The role of post-transplant anti-HLA antibodies in chronic rejection.
| Project/Area Number |
26861036
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 抗HLA抗体 / 慢性拒絶 / 小児肝移植 |
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| Outline of Final Research Achievements |
We conducted a screening of anti-HLA antibodies for patients who underwent pediatric living donor liver transplantation. In this study, we found that CNI minimization or withdrawal was an independent risk factor for DSA development and that the association between younger age and DSA development was related to reduced CNI dose for recipient growth. Additionally, subgroup analyses for patients with anti-DQ DSAs available showed that low-trough CNI was an independent risk factor for anti-class II DSA development, and that almost all high-MFI DSAs had complement-binding ability.
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| Free Research Field |
臓器・細胞移植
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