Human 3beta-hydroxysteroid dehydrogenase type 1 in human breast cancer: clinical significance and prognostic associations

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861041
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: Shinshu University
• Principal Investigator: HANAMURA Toru 信州大学, 医学部附属病院, 特任研究員 (00532053)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 乳癌 / エストロゲン / アンドロゲン / ステロイド代謝 / 内分泌療法

Outline of Final Research Achievements

The purpose of this study was to investigate the clinical significance of 3β-HSD type 1 in human breast cancer.Using immunohistochemistry (IHC), we evaluated 3β-HSD type 1 expression in 161 human breast cancers.3β-HSD type 1 expression was inversely correlated with invasive tumor size, presence of invasive region, and lymphatic involvement. 3β-HSD type 1 expression was significantly associated with decreased risk of recurrence or improved prognosis by both univariate and multivariate analyses. Our findings indicate that this enzyme is a prognostic factor in hormone-dependent breast cancer.

Free Research Field

癌の分子生物学