2016 Fiscal Year Final Research Report
Enhancement of the cell therapeutic potency using low-molecular weight heparin protamine complex
| Project/Area Number |
26861052
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 再生医療 / 細胞移植 / 脂肪由来間質細胞 / 細胞キャリア / 下部尿路障害 / 腹圧性尿失禁 |
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| Outline of Final Research Achievements |
Fragmin/Protamine Nano-Particles (F/P NPs) are recently developed as low-molecular weight, biodegradable carriers for adipose-derived stromal cells (ASCs). We examined the ability of ASCs/F/P NPs aggregates to rescue limb loss in a mouse model of hindlimb ischemia and increase in urethral resistance in a rat model of vaginal distention.
The F/P NPs augmented the effects of ASCs on angiogenesis and reversal of limb ischemia on postoperative days 7 and 14. Leak point pressure (LPP) decreased after vaginal distension (VD) and was recovered after the periurethral injection of ASCs and ASCs/F/P NPs aggregates of 7 and 14 days after VD treatment.
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| Free Research Field |
再生医療
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