Prediction of response to chemotherapy of colorectal liver metastases based on the tumor genetic profile

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861063
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Okinaka Memorial Institute for Medical Research
• Principal Investigator: Shindoh Junichi 公益財団法人冲中記念成人病研究所, その他部局等, 研究員 (90701037)
• Co-Investigator(Renkei-kenkyūsha): Kokudo Norihiro 東京大学, 医学部・肝胆膵外科, 教授 (00205361)
• Research Collaborator: Nishioka Yujiro 東京大学, 医学部肝胆膵外科 ; Yoshioka Ryuji 東京大学, 医学部肝胆膵外科 ; Gonoi Wataru 東京大学, 医学部放射線科 ; Abe Hiroyuki 東京大学, 医学部病理部 ; Okura Naoki 東京大学, 医学部放射線科 ; Yoshida Shuntaro 東京大学, 医学部消化器内科 ; Mitsui Jun 東京大学, 医学部神経内科 ; Hasegawa Kihoshi 東京大学, 医学部肝胆膵外科 ; Fukayama Masashi 東京大学, 医学部病理部 ; Tsuji Shoji 東京大学, 医学部神経内科 ; Hashimoto Masaji 虎の門病院, 消化器外科 ; Watanabe Goro 虎の門病院, 消化器外科
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 大腸癌 / 肝転移 / 化学療法 / 遺伝子変異

Outline of Final Research Achievements

Genome-wide analysis for pilot samples from 10 patients with colorectal liver metastases (CLM) revealed that polymorphism in transmembrane region of MICA gene could be a new biomarker for response to chemotherapy and postoperative prognosis. Validation analysis using samples from 58 patients confirmed very high concordance rate in MICA genotype between tumor tissue and normal liver parenchyma (96.4%) and that MICA A5.1 is associated with pathologic response to chemotherapy and better survival outcomes. These results suggest that MICA genotype can be a potential biomarker for patients undergoing chemotherapy and surgery for CLM.

Free Research Field

消化器外科学