2015 Fiscal Year Final Research Report
Analysis of malignant progression of lung adenocaricnoma
Project/Area Number |
26861123
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Respiratory surgery
|
Research Institution | Hiroshima University |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Keywords | 小型肺腺癌 / 悪性化進展 / 浸潤 |
Outline of Final Research Achievements |
Controlling invasiveness is a pivotal concept to conquer cancers. We selected guanylate binding protein 1 (GBP-1) as a candidate molecule involved in invasion of lung adenocarcinoma for further analyses. Human lung adenocarcinoma samples showed higher GBP-1level, while higher expression of GBP-1 was detected in mesenchymal-like cells than epithelial-like cells. Then, cell motility assay provided the evidence of involvement of GBP-1 in promoting lung adenocarcinoma cell motility. In addition, clinicopathological findings including immunohistochemistry for GBP-1 of patients with lung adenocarcinoma revealed the positive association between GBP-1 expression and lymph-vascular invasion. In conclusion, GBP-1 induces invasiveness of early stage lung adenocarcinoma through promoting cell motility. And might contribute to the development of new therapeutic strategies for lung adenocarcinoma.
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Free Research Field |
肺癌
|