2015 Fiscal Year Final Research Report
The effect of PPAR gamma ligand in bronchiolitis obliterans in a mouse tracheal transplant model study
| Project/Area Number |
26861127
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Respiratory surgery
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
Ohtsuka Takashi
Shimoda Masayuki
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 肺移植 / 拒絶反応 / PPARγ / Pioglitazone |
|---|
| Outline of Final Research Achievements |
The administration of pioglitazone, a PPAR gamma agonist, leads to a decrease in tracheal allograft luminal occlusions and the induction of regulatory T cell accumulation in the allograft in a mouse tracheal transplantation model. This indicates a protective role of pioglitazone against bronchiolitis obliterans. The potential mechanism of these effects includes a decrease in inflammatory cytokine production. However, the anti-inflammatory potential, and efficacy in the maintenance of transplant tolerance needs to be validated in the future.
|
| Free Research Field |
呼吸器外科学
|
