2015 Fiscal Year Final Research Report
Carcinogenesis in lung cancer with idiopathic pulmonary fibosis related to MUC expresion
Project/Area Number |
26861130
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Respiratory surgery
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Research Institution | Tokyo Medical University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Keywords | 肺癌 / 肺線維症 / 癌化機構 / 粘液過剰産生 |
Outline of Final Research Achievements |
Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal disease characterized by a progressive decline in lung function. IPF was also reported to be associated with increased risk of lung cancer as a result of the occurrence of atypical or dysplastic epithelial changes in fibrosis which progressed to invasive malignancy.Clinical and physiological parameters to predict how rapidly patients with IPF might progress, genetic and molecular features are also associated with IPF mortality. It has been shown that IPF patients who have a specific genotype in the mucin MUC5B gene polymorphism experience significantly improved survival. The purpose of this study is to assess the impact of mucin overproduction mechanism potenitially involved in carcinogenesis in lung cancer.
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Free Research Field |
肺癌外科
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