ANP-mediated vasoprotective action against cancer metastasis

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861136
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Nojiri Takashi 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (50570553)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: ナトリウム利尿ペプチド / 癌転移 / がん再発 / 抗転移療法 / 手術療法

Outline of Final Research Achievements

We have previously reported that administration of atrial natriuretic peptide (ANP) during the perioperative period reduces inflammatory response and has a prophylactic effect on postoperative cardiopulmonary complications in lung cancer surgery. In addition, we demonstrated that cancer recurrence after curative surgery was significantly lower in ANP-treated patients than in control patients (surgery alone). We showed that ANP prevents cancer metastasis by inhibiting the adhesion of tumor cells to inflamed endothelial cells.

Free Research Field

医歯薬学