Development research for high-speed and high-precision language mapping using high-density intracranial electrodes

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861140
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: The University of Tokyo
• Principal Investigator: KUNII NAOTO 東京大学, 医学部附属病院, 助教 (80713940)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 言語機能マッピング / 皮質脳波 / 皮質電気刺激マッピング / 高周波脳律動活動 / 皮質皮質間誘発電位 / トラクトグラフィー

Outline of Final Research Achievements

To improve the reliability of language mapping in brain surgery, we investigated high frequency oscillation, corticocortical evoked potential, and tractography of the arcuate fasciculus, which reflect the local cortical activity, connectivity of remote cortices, and white matter connecting language centers, respectively, and compared them with the results of electrocortical stimulation mapping, that is, the gold standard technique. The result showed the possibility that we could achieve the positive predictive value of more than 80% by combining high frequency oscillation and corticocortical evoked potential. On the other hand, the ends of the tractography were shown to be located at the periphery of the language centers.

Free Research Field

機能脳神経外科