2015 Fiscal Year Final Research Report
Research of the induction of autophagy and the suppression mechanism in MGMT activity by vorinostat
Project/Area Number |
26861141
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurosurgery
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Research Institution | Niigata University |
Principal Investigator |
Ogura Ryosuke 新潟大学, 医歯学総合病院, 医員 (70626423)
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Project Period (FY) |
2014-04-01 – 2016-03-31
|
Keywords | ボリノスタット / MGMT / 局在 / テモゾロミド / シャペロン介在性オートファジー |
Outline of Final Research Achievements |
Vorinostat, a histone deacetylase inhibitor, suppress O6-methylguanine-DNA methyltransferase (MGMT) activity, but the mechanism is unknown. In this study, we found that it was necessary to resistant to temozolomide that MGMT localized in nucleus. And MGMT overexpression in cytoplasm may be degraded by chaperone-mediated autophagy. It can be new treatment strategy to change MGMT localization by vorinostat.
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Free Research Field |
脳腫瘍
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