2015 Fiscal Year Final Research Report
Constraction of basis of glioblastoma treatment targeting for GSK3beta
| Project/Area Number |
26861142
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Nakada Mitsutoshi 金沢大学, 医学系, 教授 (20334774)
Furuta Takuya 金沢大学, 大学病院, 医員 (20646690)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | glioblastoma / GSK3beta |
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| Outline of Final Research Achievements |
We have reported that inhibition of glycogen synthase kinase 3β(GSK3β）supresses proliferation of glioblastoma cell.Existing drugs which have inhibitory effect for GSk3β inhibit cell proliferation and invasion of glioblastoma in vitro and in vivo.These drugs supress nestin positive cells, that means reduction of stemness og glioblastoma.According to analysis of expression of active form of GSK3β for surgical spiecimens, progression free survival and overall survival of patients with high level expression is worse than patients with low expression.
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| Free Research Field |
脳腫瘍
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