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2015 Fiscal Year Final Research Report

Facilitation of functional synaptic formation between grafted-iPSC-derived dopaminergic neurons and host brain neurons via cell-adhesion molecule

Research Project

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Project/Area Number 26861146
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionKyoto University

Principal Investigator

Nishimura Kaneyasu  京都大学, iPS細胞研究所, 研究員 (90527889)

Project Period (FY) 2014-04-01 – 2016-03-31
KeywordsiPS細胞 / ドパミン神経 / パーキンソン病 / 細胞移植治療 / シナプス形成
Outline of Final Research Achievements

Cell transplantation therapy using human pluripotent stem cell (PSC)-derived midbrain dopaminergic (mDA) neurons is expected to soon reach Parkinson's disease (PD) patients. Especially, neuronal innervation and functional synaptic formation between grafted-DA neurons and host striatal neurons is crucial for restoring the lost neuronal function of PD patients.
We found that systemic administration of an estradiol derivative, estradiol-2-benzoate (E2B), promotes the activation of integrin α5 and facilitates the behavioral recovery of parkinsonian model rats via the synaptic formation between grafted iPSC-derived DA neurons and host striatal neurons. These findings suggested that systemic administration of E2B provides a microenviromental cue for synaptic formation via activation of integrin α5 in host striatal neurons, thus potentially providing pharmacotheraputic benefit in humans.

Free Research Field

神経薬理学

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Published: 2017-05-10  

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