Novel approach and mechanism of immunotherapy for malignant glioma with spirulina CPS

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861154
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Kochi University
• Principal Investigator: KAWANISHI Yu 高知大学, 教育研究部医療学系臨床医学部門, 助教 (90527582)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: スピルリナ / グリオーマ / 免疫療法

Outline of Final Research Achievements

Both Spirulina CPS and E. coli LPS induced NFκB activation and their responses were suppressed by pre-incubating these polysaccharides with polymyxin B, suggesting that the chemical nature is shared between these two complex polysaccharides. Administration of anti-CD8 antibodies, anti-CD4 plus anti-CD8 antibodies or anti-asialo GM1 antibodies enhanced glioma growth, suggesting that T cells, and natural killer (NK) cells or macrophages were involved in the suppression of the tumor growth by Spirulina CPS. In this review, we focused on examining whether macrophages or NK cells are responsible for the suppression of the glioma growth. We found that both Spirulina CPS and E. coli LPS suppressed tumor growth by activating F4/80 positive macrophages. In conclusion, Spirulina CPS suppressed the tumor growth by activating both T cells and macrophages and down-regulating angiogenesis.

Free Research Field

脳神経外科学