2015 Fiscal Year Final Research Report
Role of angiotensin in thrombus formation by laser-induced cerebrovascular injury
| Project/Area Number |
26861162
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 脳微小循環 / レーザー照射 / マウス / AT1受容体 / AT2受容体 |
|---|
| Outline of Final Research Achievements |
Observation of thrombus formation after laser irradiation of murine pial arteries showed that effects of angiotensin Ⅱ type 1 (AT1) and type 2 (AT2) receptor on the process of thrombus formation and platelet behavior could be evaluated in vivo. The present study suggested that the laser-induced thrombus formation in murine pial arteries was inhibited by AT1 receptor deficiency, and was promoted by AT2 receptor deficiency.
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| Free Research Field |
脳神経外科学
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