2015 Fiscal Year Final Research Report
Analysis of metabloic characteristics of glioma stem cells
| Project/Area Number |
26861168
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 幹細胞 |
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| Outline of Final Research Achievements |
The objective of this study was to analyze the metabolic characteristics of glioma stem cells (GSCs) and identify related targetable factors. With the use of a mouse model of glioblastoma, we established GSCs that rely on glycolysis and GSCs that obtain energy mainly through the tricarboxylic acid cycle and investigated their metabolic characteristics. For each GSC fraction, we identified their preferential substrates and the enzymes supporting their metabolic profile. Furthermore, we showed that GSCs that can use the TCA cycle under normal conditions can flexibly switch to glycolysis in hypoxic conditions and that they display metabolic plasticity.
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| Free Research Field |
がん
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