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2017 Fiscal Year Final Research Report

Analysis of immuno-responsive mechanism by 5-ALA and irradiation therapy

Research Project

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Project/Area Number 26861170
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

NAKANO Yoshiteru  産業医科大学, 医学部, 助教 (10435125)

Project Period (FY) 2014-04-01 – 2018-03-31
Keywords悪性脳腫瘍 / グリオーマ / 5-ALA / PGE2 / マクロファージ / 免疫逃避機構
Outline of Final Research Achievements

A subcutaneous tumor model using a glioma cell line (RSV-M) was prepared for C3H / HeN mice and oral administration of 5-aminolevulinic acid (5-ALA) was performed, and tumor growth suppression was confirmed. 5-ALA inhibited the prostaglandin E2 (PGE2) production, which was an immunosuppressive factor in macrophages, and the expression of PGE2 synthetases COX-2 and mPGES-1 was suppressed. When macrophages treated with 5-ALA were co-cultured with RSV-M, the cytotoxic activity was confirmed in a 5-ALA concentration-dependent manner. 5-ALA released the immune escape mechanism of macrophages by PGE2, resulting in anti-glioma effect.

Free Research Field

脳腫瘍、腫瘍免疫

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Published: 2019-03-29  

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