2016 Fiscal Year Final Research Report
Identification of a novel epigenetic modifier in gliomagenesis
Project/Area Number |
26861172
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurosurgery
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Research Institution | Nagoya University |
Principal Investigator |
Ohka Fumiharu 名古屋大学, 医学系研究科, 助教 (10725724)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | 神経膠腫 |
Outline of Final Research Achievements |
In this study, we investigated the mechanisms of upregulated EZH2 in gliomagenesis. We already established a unique mouse model, which spontaneously develops glioma. Using this mouse model, we analyze the significance of EZH2 in gliomagenesis, sequentially. EZH2 is upregulated from an early stage of gliomagenesis, inducing accumulation of dysregulation of histone modification. We found that EZH2 plays pivotal roles with other histone modifier whose copy number of gene is amplified, cooperatively. Our data suggests that EZH2 might play pivotal roles in gliomagenesis via dysregulation of epigenetic alteration.
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Free Research Field |
脳腫瘍学
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