2015 Fiscal Year Final Research Report
a novel therapy targeting miRNA of clear cell sarcoma
| Project/Area Number |
26861182
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Gifu University |
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Principal Investigator |
Nagano Akihito 岐阜大学, 医学部附属病院, 講師 (60422721)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | clear cell sarcoma / miRNA / siRNA / microarray |
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| Outline of Final Research Achievements |
Clear cell sarcoma is one of malignant soft tissue sarcoma and EWS/ATF1, chimeric fusion gene, plays important role of tumorigenesis. The objective of this research is to reveal the relationship between EWS/ATF1 and microRNA (miRNA). An siRNA targeting EWS/ATF1 made miR-3127-5p to be upregulated. Transfection of miR-3127-5p to clear cell sarcoma cell line revealed both a suppression of cell proliferation and migratory capacity. These findings suggest miR-3127-5p has a potential to be a novel target of clear cell sarcoma treatment.
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| Free Research Field |
骨軟部腫瘍
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