Prevention of articular cartilage degeneration using TNC :Analysis of gene expression

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861183
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Mie University
• Principal Investigator: matsui yuriyo 三重大学, 医学(系)研究科(研究院), リサーチアソシエイト (20727680)
• Research Collaborator: HASEGAWA Masahiro 三重大学, 医学部付属病院, 講師 (40308664) ; YOSHIDA Toshimichi 三重大学, 医学系研究科, 教授 (80166959)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: テネイシンC / 変形性膝関節症 / 軟骨変性抑制

Outline of Final Research Achievements

Osteoarthritis (OA) constitutes an increasingly common medical problem for aging people. Tenascin-C (TNC) is an extracellular matrix glycoprotein. Our previous studies have demonstrated that 10μg/ml of TNC could prevent cartilage degeneration in murine models of OA.
In this study, we performed real time PCR to reveal the mechanism of preventing cartilage degeneration in vitro study. In vitro study, 10μg/ml of TNC upregulated the expression of TNC, TNFα, IL-1β, TGFβ and TIMP3. But 10μg/ml of TNC downregulated the expression of ADAMTS5.

Free Research Field

整形外科