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2015 Fiscal Year Final Research Report

Prevention of articular cartilage degeneration using TNC :Analysis of gene expression

Research Project

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Project/Area Number 26861183
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionMie University

Principal Investigator

matsui yuriyo  三重大学, 医学(系)研究科(研究院), リサーチアソシエイト (20727680)

Research Collaborator HASEGAWA Masahiro  三重大学, 医学部付属病院, 講師 (40308664)
YOSHIDA Toshimichi  三重大学, 医学系研究科, 教授 (80166959)
Project Period (FY) 2014-04-01 – 2016-03-31
KeywordsテネイシンC / 変形性膝関節症 / 軟骨変性抑制
Outline of Final Research Achievements

Osteoarthritis (OA) constitutes an increasingly common medical problem for aging people. Tenascin-C (TNC) is an extracellular matrix glycoprotein. Our previous studies have demonstrated that 10μg/ml of TNC could prevent cartilage degeneration in murine models of OA.
In this study, we performed real time PCR to reveal the mechanism of preventing cartilage degeneration in vitro study. In vitro study, 10μg/ml of TNC upregulated the expression of TNC, TNFα, IL-1β, TGFβ and TIMP3. But 10μg/ml of TNC downregulated the expression of ADAMTS5.

Free Research Field

整形外科

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Published: 2017-05-10  

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