2015 Fiscal Year Final Research Report
Treatment and prevention for fragility fracture using molecular evolution engineering and advanced adhesive technology
Project/Area Number |
26861195
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
|
Research Institution | Okayama University |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Keywords | 生体材料 / 結合性改変成長因子 / コラーゲン結合性ドメイン / BMP |
Outline of Final Research Achievements |
We have studied about treatment and prevention for fragility fracture using molecular evolution engineering and advanced adhesive technology. CBD-BMP4 showed significantly better fixing stability both in vitro and vivo than BMP4. We assessed bone regeneration using CBD-BMP4 and BMP4 within bone defect of mice and rabbits. CBD-BMP4 showed good bone regeneration. According to real-time PCR, CBD-BMP4 indicated higher expression in ALP and osteocalcin.
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Free Research Field |
整形外科
|