Hyperglycemia during acute spinal cord injury is a preventable risk factor for spinal cord injury - Translational research from animals to humans -

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861198
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Japan Organization of Occupational Health and Safety, Spinal Injuries Center (2016); Kyushu University (2014-2015)
• Principal Investigator: Kubota Kensuke 独立行政法人労働者健康安全機構総合せき損センター(研究部), 独立行政法人労働者健康安全機構総合せき損センター(研究部), 研究員(移行) (00717069)
• Research Collaborator: KOBAYAKAWA KAZU 九州大学, 大学病院, 助教 (40772322)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 脊髄損傷 / 高血糖 / 機能予後 / ミクログリア

Outline of Final Research Achievements

Under hyperglycemic conditions, both in vivo and in vitro, inflammation was enhanced through promotion of the nuclear translocation of the nuclear factor κB (NF-κB) transcription factor in microglial cells. During acute SCI, hyperglycemic mice exhibited progressive neural damage, with more severe motor deficits than those observed in normoglycemic mice. Consistent with the animal study findings, a Pearson χ2 analysis of data for 528 patients with SCI indicated that hyperglycemia on admission was a significant risk predictor of poor functional outcome. Moreover, a multiple linear regression analysis showed hyperglycemia at admission to be a powerful independent risk factor for a poor motor outcome. Manipulating blood glucose during acute SCI in hyperglycemic mice rescued the exacerbation of pathophysiology and improved motor functional outcomes. These results suggest that glycemic control may be needed to improve recovery after acute spinal cord injury in human patients.

Free Research Field

脊髄損傷