2015 Fiscal Year Final Research Report
Properties of silver oxide-containing hydroxyapatite coating implant
| Project/Area Number |
26861199
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Saga University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 銀 / ハイドロキシアパタイト / 感染 / 人工関節 |
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| Outline of Final Research Achievements |
Our preparation of silver oxide-containing hydroxyapatite (Ag-HA) showed the property of both osteoconductivity of HA and antibacterial activity of silver, without any adverse reaction to silver. Furthermore, it was able to prevent biofilm formation, which plays important role in infection, in vitro and in vivo experiments. In the crinical trial of Ag-HA coated implants for total hip arthroplasty, patients had improved their pain, function and activity of daily living without any side effects.
Ag-HA is promising as a means of reducing postoperative infection, preventing decreased quality of life, and obtaining favorable outcomes in patients undergoing prosthetic arthroplasty.
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| Free Research Field |
人工関節
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