2016 Fiscal Year Final Research Report
Tissue-engineered vascularized bone grafts fabricated with osteogenic cell sheet for the reconstruction of segmental bone defect
| Project/Area Number |
26861205
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 四肢機能再建学 |
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| Outline of Final Research Achievements |
The inclusion of vascular bundles can further enhance the bone-forming capability of bone substitutes by promoting tissue neovascularization. In this study, the authors developed a novel vascularized tissue-engineered bone scaffold composed of osteogenic matrix cell sheets wrapped around vascular bundles within β-tricalcium phosphate ceramics. Four weeks after subcutaneous transplantation in rats, making use of the femoral vascular bundle, vascularized tissue-engineered bone demonstrated more angiogenesis and higher osteogenic potential than the controls. After the elevation of vascularized tissue-engineered bone with ligating distal part of vascular bundle, the vascularized tissue-engineered bone can maintain their angiogenesis and higher osteogenic potential. This novel method for preparing vascularized tissue-engineered bone scaffolds may promote the regeneration of large bone defects, particularly where vascularization has been compromised.
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| Free Research Field |
骨再生医療
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