Effects of neurosteroid on pain transmission in the rat dorsal horn.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861224
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Niigata University
• Principal Investigator: YAMAMOTO Goh 新潟大学, 医歯学総合病院, 医員 (40710463)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 神経ステロイド / デヒドロエピアンドロステロンサルフェート / 脊髄後角 / シグマ1受容体 / 痛覚過敏

Outline of Final Research Achievements

Dehydroepiandrosterone sulfate (DHEAS) is a kind of neurosteroids and is known to have pronociceptive effects on the spinal cord. However, its underlying mechanisms has not been elucidated.We investigated the effect of DHEAS on excitatory synaptic transmission in the dorsal horn neurons of the adult rat spinal cord using electrophysiological technique.We demonstrated that DHEAS enhanced excitatory transmission and suppressed inhibitory transmission in spinal lamina II neurons, resulting in showing pronociceptive effects on the spinal cord.

Free Research Field

医歯薬学 麻酔　ペインクリニック