Analysis of opioid effects against tumor proliferation and life prognosis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861232
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Tottori University
• Principal Investigator: Otsuki Akihiro 鳥取大学, 医学部附属病院, 助教 (00379637)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: オピオイド / オピオイド受容体 / がん細胞 / A549 / モルヒネ

Outline of Final Research Achievements

When tumor cells are treated with the opioid analgesics morphine and fentanyl, high concentrations morphine and fentanyl inhibit tumor proliferation. However, in some cases medium to high concentration morphine showed proliferation promoting action. This results are thought that the effect on cell division, the effect on cell death, the influence on cell adhesion, etc. are combined and contributed to the survival rate of tumor cells. It may also be related to the difference in the effect on cell proliferation that the change in the expression level of opioid receptor after opioid administration is different between morphine and fentanyl.

Free Research Field

麻酔学