2016 Fiscal Year Final Research Report
Direct cardioprotective effect of dexmedetomidine against ischemia/reperfusion injury in hypertensive hypertrophied myocardium
| Project/Area Number |
26861237
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Anesthesiology
|
|---|
| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
HIRATA Naoyuki
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | デクスメデトミジン / 虚血再灌流障害 / 高血圧 / イミダゾリン |
|---|
| Outline of Final Research Achievements |
The present study revealed that dexmedetomidine maintains the direct cardioprotective effect against ischemia/reperfusion injury in hypertensive hypertrophied myocardium via different mechanism from normal healthy heart. Dexmedetomidine protects normal healthy heart through eNOS phosphorylation via alpha2 adrenoreceptor. On the other hand, the results of the present study revealed that the cardioprotective effect of dexmedetomidine in hypertensive hypertrophied myocardium is via imidazoline 1 receptor, which remains in normal expression level, not via alpha2 adrenoreceptor, which is up-regulated in hypertrophied myocardium. Furthermore, our data indicated that eNOS phosphorylation does not contribute to the cardioprotective effect of dexmedetomidine in hypertensive hypertrophied myocardium.
|
| Free Research Field |
麻酔科学
|
