Mechanisms for antinociceptive effect of beta-edorphin on the spinal dorsal horn.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861247
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Dokkyo Medical University
• Principal Investigator: Terashima Tetsuji 獨協医科大学, 医学部, 助教 (30526398)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: βエンドルフィン / オピオイド受容体 / サブスタンスP / 脊髄後角 / 内因性鎮痛 / 急性炎症モデル / NK1受容体 / c-Fos

Outline of Final Research Achievements

To further elucidate the mechanisms for antinociceptive effects of beta-endorphin on spinal dorsal horn, we evaluated the effects of beta-endorphin with or without selective opioid receptor antagonists on formalin-induced acute pain model. Intrathecal beta-endorphin inhibited the release of substance P from primary afferent (presynaptic): neurokinin 1 receptor internalization reflects release of substance P, mu-antagonist reversed the effects, but delta-antagonists did not reverse. This result implied that antinociceptive effects for beta-endorphin through delta-opioid receptor associated with another substance P release from primary afferent mechanism.

Free Research Field

医歯薬学