Elucidation of endothelial cell function in severe pathology

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861248
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Kyorin University
• Principal Investigator: Uzawa Kohji 杏林大学, 医学部, 助教 (30530703)
• Research Collaborator: USHIYAMA Akira ; YOROZU Tomoko ; MIYAO Hideki
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 輸液 / グリコカリックス / 内皮細胞 / ヒドロキシエチルスターチ

Outline of Final Research Achievements

The patient's prognosis is very bad at severe condition during sepsis or massive bleeding. The purpose of this research is to improve the prognosis by elucidating the pathophysiology of peripheral circulation in the serious conditions. Using a mouse model (Dorsal Skinfold Chamber (DSC)), which can be visualized in vivo, microcirculation level, lifesaving with mouse group and hydroxyethyl starch (HES 130) rescued with physiological saline infusion. We compared the images of peripheral circulation in the VOL group that we did over time. In sepsis model mice, vascular permeability was suppressed in the VOL group. In the blood removal model also, the vascular hyperpermeability was suppressed, the 7-day survival rate was improved, and the blood gas data was improved.

Free Research Field

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