2016 Fiscal Year Final Research Report
Analysis of TRPV3 function for therapeutic target of the cold pain
| Project/Area Number |
26861253
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 冷痛覚過敏 / TRPV3 |
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| Outline of Final Research Achievements |
Cold hyperalgesia occurs frequently in patients using anticancer drugs such as oxaliplatin, but effective therapeutic strategy remains to be established. The response to noxious cold stimuli was increased in a gain-of-function mutant rat of TRPV3 gene which is involved in the warm sensation. TRPV3 was expressed in the primary sensory neuron that especially transmits pain sensation. It was suggested that TRPV3 channel may be involved in cold pain through the interaction with TRPA1 channel, which is important for cold sensitivity. Functional analysis of TRPV3 may help the understanding of the molecular mechanism and provide a novel target for medication of cold pain.
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| Free Research Field |
実験動物学
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