2016 Fiscal Year Final Research Report
An attempt to improve liver disorder after hepatectomy
| Project/Area Number |
26861254
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Kindai University |
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Principal Investigator |
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 肝臓切除 / voluntary exercise / 再生障害 / 肝虚血 |
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| Outline of Final Research Achievements |
Intermittent hepatic blood flow obstruction, known as the Plingle method, is performed to control the intraoperative bleeding during partial hepatectomy and to increase safety. However, long-term ischemia causes delayed liver injury and is involved in regenerative disorders. The authors obtained the finding that voluntary exercise (VE) induces survival rate and cranial nerve regeneration in rats with stroke. Exercise is known to promote improvement of liver resection surgery, and it was examined whether VE induces survival rate and liver regeneration.
Liver regeneration increased by approximately 60% 3 days after resection. There was no significant difference in liver regeneration rate between Sed group and VE group. Although there is no difference at the present time, we are investigating whether improvement of long-term prognosis and survival rate in the VE group is expected.
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| Free Research Field |
集中治療
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