2015 Fiscal Year Final Research Report
Analysis of Prostate cancer-related exosome
| Project/Area Number |
26861265
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Gifu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 前立腺癌 / エクソソーム |
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| Outline of Final Research Achievements |
There is a great need of the development of novel diagnostic strategies that target the castration-resistant prostate cancer. One of the potential strategies is the use of microvesicles including exosomes secreted from prostate cancer cells as a tool for diagnosis. Prostate cancer related exosome included androgen receptor. mRNA analysis of prostate cancer-related exosome derived from prostate cancer cell line showed that androgen receptor and its variant were detectable. Antibody conjugated beads was capable of isolation of prostate cancer-related exosomes from patient’s blood. The results showed that the amount of isolated exosomes was higher in advanced and chemo-resistant prostate cancer patients than in prostate cancer patients without metastasis and healthy volunteers. Overall, this study showed that analysis of prostate cancer-related exosomes will enhance the research on prostate cancer.
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| Free Research Field |
泌尿器科
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