2015 Fiscal Year Final Research Report
The role of 5-HT3 receptor in bladder sensation
| Project/Area Number |
26861267
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 過活動膀胱 / 5-HT3受容体 |
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| Outline of Final Research Achievements |
This study investigated the role of serotonin type 3 receptor (5-HT3 receptor) in bladder sensation. I found that 5-HT3 receptor is abundantly expressed on primary bladder afferent nerves, activation of 5-HT3 receptor causes bladder hyperactivity, and blockade of 5-HT3 receptor inhibits the cystitis-induced bladder hyperactivity in mice. These findings indicate the novel mechanisms of bladder hyperactivity mediated by 5-HT3 receptor, and suggest that 5-HT3 receptor may be a potential therapeutic target for overactive bladder syndrome.
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| Free Research Field |
神経泌尿器科
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