2015 Fiscal Year Final Research Report
Mechanism of metastasis of bladder cancer cells via decreased expression of delta N p63 caused by adhesion to extracellular matrix
| Project/Area Number |
26861268
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Osaka University |
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Principal Investigator |
Yoshida Takahiro 大阪大学, 医学(系)研究科(研究院), 寄附講座助教 (80583624)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 膀胱癌 / 転移 / p63 / 細胞外基質 |
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| Outline of Final Research Achievements |
The dissemination of bladder cancer cells is supposed to be a major cause of multicentricity of bladder cancer. Clarifying mechanism of the dissemination can lead to development of new therapy to suppress intravesical relapse. We discovered that ΔNp63α was rapidly degraded when clusters of bladder cancer cells attached to extracellular matrix. We originally developed experimental model which mimic the dissemination of cancer cells. Using this experimental model, degradation of ΔNp63α was shown to be involved in the dissemination.
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| Free Research Field |
膀胱癌、分子生物学
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