Crosstalk between epithelial-mesenchymal transition and castration resistance in prostate cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 26861273
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Kyushu University
• Principal Investigator: Shiota Masaki 九州大学, 医学(系)研究科(研究院), 助教 (20635445)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 前立腺癌 / 去勢抵抗性 / 上皮間葉転換

Outline of Final Research Achievements

This study aimed to figure out the interaction between epithelial-mesenchymal transition and castration resistance, and to apply it to clinics. As a result, Twist1/androgen receptor signaling molecularly mediated crosstalk between epithelial-mesenchymal transition and castration resistance. As well, an inhibitor for epithelial-mesenchymal transition combined with androgen-deprivation therapy seems to be a promising therapeutic to prostate cancer.

Free Research Field

泌尿器腫瘍