Development of thermotherapy using magnetic nanoparticles for bladder cancer and elucidation of its healing mechanism

2016 Fiscal Year Final Research Report

• Project/Area Number: 26861283
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: KOBAYASHI Daichi 名古屋市立大学, 大学院医学研究科, 研究員 (80570704)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: MCL / 膀胱がん / 温熱治療

Outline of Final Research Achievements

We have developed a new treatment method (MCL Thermotherapy) that can specifically warm cancer lesions using magnetic nanoparticles and reported the therapeutic effect on various cancers. We examined the effectiveness of MCL Thermotherapy against bladder cancer this time. MCL has high cell affinity and proved to be significant adsorption to bladder cells. Moreover, not only direct tumor shrinkage effect but also enhancement of tumor immunity via immunity induction cytokine was observed. MCL thermotherapy proved to be an effective treatment for highly sensitive bladder cancer of immunotherapy.

Free Research Field

泌尿器科腫瘍