2016 Fiscal Year Final Research Report
The number of cancer stem cell contribute BCG resistance of the urinaly CIS
| Project/Area Number |
26861289
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Nara Medical University |
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Principal Investigator |
Inoue Takeshi 奈良県立医科大学, 医学部, 助教 (30719539)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 膀胱癌 / 上皮内癌 / がん幹細胞 / DNAメチル化 |
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| Outline of Final Research Achievements |
The purpose of this study is to establish the molecular markers which enables to
diagnose the BCG resistant CIS of the bladder, that is focused on cancer stem cell markers or EMT markers. Our in vitro study revealed the number of stem cell marker positive cells prescribed the BCG resistance. On the other hands, in vivo study, we could not find the correlations between BCG resistance and the number of cells which were positive for stem cell markers. However, DNA methylation level of the stem cell genes were significantly low in the BCG resistant cases. These result showed that DNA methylation regulate the expression of stem cell genes.
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| Free Research Field |
がん幹細胞
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